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Molecular Devices, LLC
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    • 제품

      새로운 DispenCell™ Single-Cell Dispenser 기술은 단일 세포주를 3배 더 빠르고 저렴한 비용으로 분리합니다.

      • 쉽고 직관적인 설정
      • 클론형성능과 추적 가능성의 즉각적인 증거
      • 고유한 기술로 세포 샘플을 부드럽게 처리
      • 벤치탑 크기  
        설계
      • 특허받은  
        일회용 팁
      DispenCell™ Single-Cell Dispenser 기술

      최적화된 3D 조직과 오가노이드 실험과정을 위한 BioAssemblyBot의 6축 로봇 팔을 갖춘 자동화된 High-Content Screening 솔루션

      BioAssemblyBot의 6축 로봇 팔

    • Microplate Reader
      SpectraMax Mini Multi-Mode Microplate Reader
      Multi-Mode Reader
      • SpectraMax i3x
      • SpectraMax iD3/iD5
      • SpectraMax M 시리즈
      • FlexStation 3
      • SpectraMax Mini
      SpectraMax ABS 마이크로플레이트
      흡광(Absorbance) 리더기
      • SpectraMax ABS/ABS Plus
      • SpectraMax VersaMax
      • SpectraMax QuickDrop
      • CMax Plus
      Fluorescence Reader
      Fluorescence Reader
      • SpectraMax Gemini
      SpectraMax Luminescence
      발광(Luminescence) 리더기
      • SpectraMax L

       

      MultiWash+ Washer
      Stacker 및 Washer
      • StakMax Stacker
      • AquaMax Washer
      • MultiWash+ Washer
      • MultiWash–C 微孔板洗板机
      SoftMax Pro 데이터 획득
      분석 소프트웨어
      • SoftMax Pro 소프트웨어
      • SoftMax Pro GxP Software
      GxP 솔루션
      GxP Compliance Solution
      • SoftMax Pro GxP Software
      • 소프트웨어 설치와 Validation 서비스
      • IQ/OQ/PM 서비스
      • SpectraTest Validation Plate
      실험실 자동화와 맞춤화
      실험실 자동화와 맞춤화
      • 플레이트 기반 High-Throughput Assay를 위한 실험실 자동화
    • 세포 Imaging 시스템
      ImageXpress Pico Automated Cell Imaging System
      Automated Cell Imaging Systems
      • ImageXpress Pico
      • ImageXpress Nano
      High-Content Imaging
      High-Content Imaging
      • ImageXpress Confocal HT.ai
      • ImageXpress Micro Confocal
      • ImageXpress Micro 4
      StratoMineR 분석
      Acquisition & Analysis Software
      • IN Carta
      • StratoMineR
      • MetaXpress
      • CellReporterXpress
      • MetaMorph
      실험실 자동화와 맞춤화
      실험실 자동화와 맞춤화
      • High-Throughput, High-Content Screening(HCS)을 위한 실험실 자동화
      • BioAssemblyBot 400 Bioprinter 자동화 HCS 솔루션
    • 클론 스크리닝
      Clone Pix 시리즈
      포유류 콜로니 피킹
      • ClonePix 2
      QPix 미생물 콜로니 피커
      미생물 콜로니 피킹
      • QPix 420
      • QPix 450/460
      • QPix HT
      CloneSelect Imager FL
      단일 세포 Imaging
      • CloneSelect Imager
      • CloneSelect Imager FL
      DispenCell Single-Cell Dispenser
      단일 세포 분리
      • DispenCell Single-Cell Dispenser
      실험실 자동화
      실험실 자동화와 맞춤화
      • High-Throughput 클론 스크리닝을 위한 실험실 자동화
      CloneMedia와 XP Media
      배지 및 시약
      Clone Screening Assay kit
      Clone Screening Assay kit
    • FLIPR Penta
      FLIPR Penta
      FLIPR Penta
      • FLIPR Penta High-Throughput 세포 스크리닝 시스템
      Screenworks
      분석 소프트웨어
      • ScreenWorks 소프트웨어
      • Peak Pro 2 소프트웨어 모듈
      Flipr Assay 키트
      FLIPR Assay 키트
      • 칼슘 Assay 키트
      • 칼륨 분석 키트
      • 막전위 분석키트
      • EarlyTox 심장 독성 키트
    • Axon Patch-Clamp
      투명
      Amplifier
      • Axopatch 200B 콘덴서
      • MultiClamp 700B
      • Axoclamp 900A
      투명
      Digitizer
      • Axon Digidata 1550B Low
      투명
      분석 소프트웨어
      • pCLAMP 11 소프트웨어 제품군
    • 기타
      Threshold Immunoassay System
      Threshold Immunoassay System
      Geneppix 미세배열 스캐너
      Genepix 미세배열 스캐너
      Imagexpress Micro Xls
      Imagexpress Micro xls
      인증 리퍼브
      인증 리퍼브
      IDBS 솔루션
      IDBS R&D 클라우드 솔루션
    • 분석 시약(assay kit)
      심장 독성
      • EarlyTox 심장 독성 키트
      Cell viability
      • EarlyTox Cell Integrity Kit
      • EarlyTox Cell Viability Assay Kit
      DNA 정량 분석
      • Spectramax Quant dsDNA Assay 키트
      Elisa, western blot
      • CatchPoint SimpleStep ELISA 키트
      • ScanLater Western Blot Assay 키트
      gpcr
      • FLIPR 칼슘 Assay 키트
      • Fura-2 QBT 칼슘 키트
      • CatchPoint cAMP 형광 Assay 키트
      • CatchPoint cGMP 형광 Assay 키트
      이온 통로
      • FLIPR 칼륨 Assay 키트
      • FLIPR 막전위 Assay 키트
      IGG 정량분석
      • ValitaTiter
      • CloneDetect
      Reporter gene
      • Spectramax Glo Steady-Luc Reporter Assay Kit
      • Spectramax DuoLuc Reporter Assay Kit
      Transporter
      • QBT Fatty Acid Uptake Assay Kit
      • 신경전달물질 수송체 흡수 Assay 키트
      기타
      • Contamination Detection
      • Enzyme - IMAP Assay
    • 액세서리 및 소모품
      Microplate Reader
      • 384 Well SBS
      • 384 Well High Sample Recovery Plate
      • Deep-well Plate
      • Low Profile Microplate
      • SpectraDrop Micro-Volume Microplate
      • SpectraMax Injection cartridge with SmartInject Technology
      • SpectraMax MiniMax 300
        Imaging Cytometer
      • Western Blot Cartridge
      • 96孔微孔板
      클론 스크리닝
      • Adjustable Petri Dish and Microplate Holder
      • Bioassay QTrays
      • Calibead
      • 캡 매트 및 뚜껑
      • 크로마 필터
      • 세정 및 살균 솔루션
      • CloneSelect Single-Cell Printer Cartridge
      • QPix 핀 및 헤드
      • QReps 레플리케이터
      Axon Patch-Clamp
      • Soft Panel Amplifier Control
      Spectra Img
  • 연구 분야
    • 응용 분야

      Molecular Devices, Cellesce 인수로 환자 유래 오가노이드 특허 기술 추가

      2022년 12월 6일

      • Cellesce의 동종 업계 최초 기술로 대규모 약물 Screening을 위한 일관적인 환자 유래 오가노이드를 생성합니다.
      • 인수를 통해 Molecular Devices의 3D 생물학 솔루션 혁신 기업으로서의 입지를 강화합니다.
      • 결합된 전문 지식으로 신약 개발을 위해 생리학적으로 연관된 세포 모델의 채택을 업계에서 가속화할 것입니다.

       

      OIC 방문하기

      언론 보도 읽기

      Cellsce
      응용 분야를 위한 Spectra
    • 코로나바이러스 (COVID-19)
      코로나19
      코로나19 연구
      관련 솔루션
      코로나19
      코로나19 관련
      새로운 뉴스
      코로나19
      백신 개발 워크플로
      감염병 연구 응용 분야
      백신 연구
      연구 응용 분야
    • 연구분야 (Stem Cell, Cancer)
      투명
      3D Cell Model
      투명
      암 연구 솔루션
      투명
      Cell Line Development
      투명
      신약 개발
      투명
      식품 및 음료
      투명
      유전자 편집(CRISPR/Cas9)
      투명
      오가노이드 연구
      투명
      줄기세포 연구
      투명
      독성학
    • Microplate Reader
      투명
      세포 건강 상태 (Cell Health)
      투명
      Cellular Signaling
      투명
      ELISA
      투명
      미생물학과 오염물질
      투명
      핵산(DNA/RNA) 측정과 분석
      투명
      단백질 측정, 정량분석, 분석
      투명
      관련 분석법: 측정 모드
      • 흡광(Absorbance)
      • 형광(Fluorescence)
      • 형광 편광
      • 발광(Luminescence)
      • TRF, TR-FRET 및 HTRF
      • Western Blot
    • 세포 Imaging 시스템
      투명
      Cell Counting
      투명
      세포 이미징 및 분석
      투명
      세포 Migration Assay
      투명
      세포 염색
      투명
      Live Cell Imaging
      투명
      Neurite Outgrowth
      투명
      장기 칩
      투명
      오가노이드
      투명
      Spheroids
    • 클론 스크리닝
      투명
      Cell line development 실험과정
      투명
      단클론항체(mAb)
      • 하이브리도마
      • 파지 디스플레이
      • 단일클론항체 생산
      투명
      Monoclonality
      투명
      합성 생물학
    • FLIPR Penta
      투명
      GPCR(G protein-coupled receptor)
      투명
      이온 채널
      투명
      Cardiotoxicity(심장독성)
    • Axon Patch-Clamp
      투명
      전기생리학(Patch Clamp)
  • 자료
    • 자료
    • 관련 자료 검색
      메뉴 자료 아이콘/응용 분야 노트
      Application Note
      메뉴 자료 아이콘/레퍼런스
      레퍼런스
      Ebook 아이콘
      eBook
      메뉴 자료 아이콘/Scientific Poster
      Scientific Poster
      메뉴 자료 아이콘/튜토리얼 및 영상
      동영상 및 웨비나

      검색

    • 블로그 – 실험실 노트
      스페이서
      Assay에 대한 고객 사례…
      스페이서
      3D organoids and…
      How 3D Cell Models Will Shape the Future of Drug Discovery
      2023년 3월 7일 Target discovery and drug development rely heavily on 2D cell and animal models to decipher efficacy and toxic effect of drug candidates. Yet, 90% of candidates fail to…
      더 알아보기  
    • 고객 사례 소개

      다른 연구자들이 제품과 솔루션을
      어떻게 사용했는지 확인해보세요.

    • 혁신 기술
      투명
      AI, 머신러닝 및 딥러닝
      투명
      AgileOptix 스피닝 디스크 기술
      투명
      자동 초점
      투명
      디지털 공초점 옵션
      투명
      고함량 Screening
      투명
      HumSilencer
      투명
      레이저 조명
      투명
      QuickID 표적 이미지 획득
    • 관련 분석법
      투명
      흡광(Absorbance)
      투명
      전기생리학
      투명
      형광(Fluorescence)
      투명
      형광 편광(FP)
      투명
      발광(Luminescence)
      투명
      TRF, TR-FRET 및 HTRF
      투명
      Water Immersion Objective
      투명
      Western Blot
    • 동영상 갤러리
      투명
      Microplate Reader
      투명
      세포 Imaging 시스템
      투명
      Flipr 시스템
      투명
      클론 스크리닝
      투명
      Axon Patch-Clamp
      투명
      주문형 웨비나
  • 서비스 및 지원
    • 서비스 및 지원
    • 개요
      Spectra 로고
      SpectraNet 고객 관리 포털
      GxP 컴플라이언스
      GxP 컴플라이언스 솔루션
      실험실 자동화와 맞춤화
      실험실 자동화와 맞춤화
      전문 서비스
      전문 서비스

      기술 지원

      미국 본사  
      +1 800-635-5577  
      월~금, 오전 7시~오후 5시 PST

      유럽  
      +44-118-944-8000  
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      내가 있는 지역의 담당자 확인하기

      SpectraNet 고객 포털  

    • 고객 포털 - Spectranet
      Spectranet

      INTRODUCING OUR NEW CUSTOMERCARE PORTAL

      SpectraNet is an intuitive, simple-to-use, self-service customer portal providing a new level of experience available 24/7.

      Create your account today to get full access to integrated content and world-class customer service.

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    • GxP 컴플라이언스 솔루션
      GxP Softmax Pro GxP 소프트트웨어
      SOFTMAX PRO GXP 소프트웨어
      GxP 소프트웨어 설치
      소프트웨어 설치와 Validation 서비스
      GxP Spectratestt Validation Plate 재인증
      SPECTRATEST Validation Plate
      IQ OQ 서비스
      IQ/OQ/PM 서비스
    • 실험실 자동화
      실험실 자동화와 맞춤화
      실험실 자동화와 맞춤화
      High Content Screening HCS
      High-Throughput, High-Content Screening
      • BioAssemblyBot 400 Bioprinter 자동화 HCS 솔루션
      플레이트 기반 High-Throughput Assay
      플레이트 기반 High-Throughput Assay
      High-Throughput 클론 스크리닝
      High-Throughput 클론 스크리닝
    • 전문 서비스
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  • 회사
    • 회사

      Molecular Devices, 오스트리아의 글로벌 R&D 허브 확장

      2022년 10월 12일        
      더 큰 부지는 Cell Line Development, 오가노이드 개발, 신약 개발을 개선하기 위한 Screening 솔루션을 발전시키기 위한 협업 공간인 잘츠부르크의 오가노이드 혁신 센터의 미래 기지가 될 것입니다.

       

      OIC 방문하기

      언론 보도 읽기

      Austrian Research & Development Center의 리본 커팅 기념식
      응용 분야를 위한 Spectra
    • 회사 소개

      Molecular Devices는 실리콘 밸리를 기반으로 제약 및 연구의 스크리닝과 효과적인 분석이 가능한 솔루션을 40년에 걸쳐 개발하고 공급해 왔습니다.

    • 리더십

      당사의 다양한 경험, 비즈니스 인사이트 및 공동의 목표의식은 직원들이 잠재력을 최대한 발휘하도록 독려하기 위한 당사의 일상적인 결정에 추진력을 부여합니다.

      리더십

    • 채용

      당사의 팀 중심 기업 문화는 생각과 관점의 다양성과 강력한 신뢰 관계를 보장합니다.

    • 뉴스룸
      투명
      뉴스
      투명
      보도 내용
      Silver Sponsor Molecular Devices at Society for Laboratory Automation and Screening 2023 International Conference and Exhibition
      Feb 22, 2023 Showcasing new industry collaborations, automated technology, and workflow innovations that span 3D biology, cell line development, and drug…
      Read more  
    • 이벤트
      Focus on Microscopy (FOM)
      Conference | Europe | Porto, Portugal, Europe– Apr 02 – Apr 5, 2023 FOM2023 continues a long-standing (since 1988), yearly conference series on the latest innovations and developments in (optical) microscopy and their…
      Read more  
      Imaging User Meeting 2023
      Conference | Europe | Copenhagen, Denmark– May 09 – May 10, 2023 Ideal for both current ImageXpress system users and those wanting to learn more about high-content, high-throughput, automated or 3D imaging, our…
      Read more  
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  1. Home
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  4. Engineering Next-gen Organoids with Automated Lab Workflows at #SLAS2022
Molecular Devices Lab Notes

Engineering Next-gen Organoids with Automated Lab Workflows at #SLAS2022

  • January 27, 2022
  • Oksana Sirenko, PhD | Angeline Lim, PhD

SLAS2022, the Society for Lab Automation and Screening conference offered another exciting year for learning about innovative laboratory technologies. Whether you attended in-person or visited us online at our virtual events page, we were excited to share new methods and protocols to automate your complex biology workflows.

Here’s a brief overview of our poster presentations that run the gamut of valuable topics — from new advancements in engineering next-generation organoids to developing an automated lab workflow for 3D cell culture, monitoring, and high-content imaging.

 

Scientific Poster Presentations

  1. Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology
  2. Automation of the organ-on-a-chip assay: automated culture, imaging, and analysis of angiogenesis
  3. Automation-based 3D organoid culture workflow with deep-learning-based label-free image analysis
  4. Simplified, user-friendly, automated workflow for phenotypic profiling based on the Cell Painting assay
  5. Assessing thrombin generation with the TECHNOTHROMBIN TGA kit on the SpectraMax i3x Multi-Mode Microplate Reader

 

1. Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology

Authors: Oksana Sirenko, PhD, Sr. Scientist; Krishna Macha, PhD, Research Scientist; Angeline Lim, PhD, Applications Scientist

ImageXpress Pico Automated Imaging

3D cell models representing various tissues were successfully used for studying complex biological effects, tissue architecture, and functionality. However, the complexity of 3D models remains a hurdle for the wider adoption in research and drug screening. 

Here we describe a workflow for automation of organoid culture. The automated method utilizes an integrated work-cell, consisting of several instruments providing automated cell culture, monitoring, and high-content imaging. The integrated system includes our ImageXpress® Confocal HT.ai High-Content Imaging System, automated CO2 incubator, automated liquid handler (Biomek i7), as well as a collaborative robot. We developed methods for automating the seeding, media exchange, and monitoring of intestinal organoids development. In addition, the method allows for automation of compound testing and evaluation of phenotypic changes.

Register for our poster presentation where we’ll discuss our methods and demonstrate the tools used to increase throughput and automate organoid assays and compound screening. We’ll also propose analysis approaches that allow you to gain more information about these complex systems, disease phenotypes, and compound effects. 

 

Register to download SLAS posters

 

2. Automation of the organ-on-a-chip assay: automated culture, imaging, and analysis of angiogenesis

Authors: Angeline Lim, PhD, Applications Scientist; Oksana Sirenko, PhD, Sr. Scientist; Arthur Stok, Matthew Delport, Product Manager, MIMETAS; Francis Enane, Bhagya Wijayawardena

Automation of the orgaon on a chip assay

There is a critical need for biological model systems that better resemble human biology. Three-dimensional (3D) cell models and organ-on-a-chip structures representing various tissues were successfully used for studying complex biological effects, tissue architecture, and functionality. The OrganoPlate® was developed as an organ-on-a-chip platform allowing the formation of 3D microfluidic-based, long-term cultures of live cells. However, the complexity of 3D models remains a hurdle for wider adoption in research and drug screening. Automation of the cell culture, assays, and analysis can provide the tools necessary to facilitate and scale up the use of organ-on-a-chip systems.

Here, we describe a workflow for automating organ-on-a-chip culture, as well as monitoring and automating cell analysis. This automated method utilizes an integrated work-cell consisting of several instruments that allow the automation and monitoring of cell culture. We developed methods for the automation of cell seeding, media exchange, and for monitoring the development and growth of 3D vasculature. In addition, these methods facilitate automated compound testing and evaluation of toxicity effects. We have used the angiogenesis assay as an example of the automation process.

Register for our poster presentation where we review the phenotypic readouts that allowed for quantitative characterization of the extent and complexity of the angiogenic sprouts in 3D. We’ll also discuss how the automated method designed is extensively applicable for compound screening and using organ-on-chip technology in a high-throughput manner. 

 

Register to download SLAS posters

 

3. Automation-based 3D organoid culture workflow with deep-learning-based label-free image analysis

Authors: Angeline Lim, PhD, Applications Scientist; Misha Bashkurov, PhD, Product Owner; Joe Chen, Automation Solutions Engineer; Oksana Sirenko, PhD, Sr. Scientist

Automation based 3d organoid culture

The 3D cell culture model system is increasingly popular because it recapitulates the in vivo microenvironment better than 2D cell cultures. 3D organoids are cellular aggregates derived from pluripotent stem cells or adult stem cells and can self-organize into organ-like structures. These organoids have the capacity for stable differentiation and rapid growth and, as such, the organoid model system offers huge potential in disease modeling, drug screening, and precision therapy.

The technologies available for using organoids as a model system are still in their infancy compared to the more established 2D culture or animal models. More development is needed to address the reproducibility of organoids between batches and to standardize and improve the process of organoid culture. In addition, current protocols for the generation and maintenance of organoids are complex, time-consuming, and require extensive manual handling.

Register for our poster presentation as we demonstrate the feasibility of using an automated work cell for the culture and monitoring of 3D pulmonary organoids. These results provide the foundational workflow which can be adapted for other 3D cell models such as intestinal, brain, or patient-derived tissues, and enable scaling-up of organoid production for other downstream applications.

 

Register to download SLAS posters

 

4. Simplified, user-friendly, automated workflow for phenotypic profiling based on the Cell Painting assay

Authors: Angeline Lim, PhD, Applications Scientist; Michael Hayes, PhD, Beckman Coulter Life Sciences; Francis Enane, PhD, Sr. Applications Scientist, Beckman Coulter Life Sciences; David Egan, PhD, Co-founder and CEO, Core Life Analytics; Victor Wong, PhD, Application Scientist, Core Life Analytics

Automated workflow for phenotypic profiling

Multiparametric high-content screening approaches, such as the Cell Painting assay, are increasingly being used in many applications ranging from drug discovery programs to functional genomics screening. The Cell Painting assay uses up to six fluorescent dyes to label and visualize a variety of organelles at the single-cell level. Morphological features extracted from the assay give unique cellular “signatures” that provide an overview of the cell. 

Cell Painting assays are typically carried out at scale with multiple assay plates. The workflows can be time and labor-intensive, taking several days to complete a screen. The use of automation that includes liquid handlers could help to streamline these processes, saving valuable user time and increasing assay throughput. In addition, the sheer volume of data generated from these experiments requires powerful software and computational tools to extract meaningful information. The computing requirements needed to run the analysis of these large datasets may be beyond the technical means of smaller research labs. 

Here, we developed a complete automated workflow for the Cell Painting assay with the added benefits of reduced hands-on time and user handling errors, with increased assay throughput.

 

Register to download SLAS posters

 

5. Assessing thrombin generation with the TECHNOTHROMBIN TGA kit on the SpectraMax i3x Multi-Mode Microplate Reader

Authors: Cathy Olsen, PhD, Application Scientist

Assessing thrombin generation

Assessing the generation of thrombin in a plasma sample allows one to better understand coagulation mechanisms. To meet the needs of researchers to determine the time-dependent changes in thrombin concentrations on a flexible platform, Technoclone has developed a plate reader-compatible kinetic assay format, the TECHNOTHROMBIN® TGA kit, using a fluorogenic substrate. Cleavage of the substrate occurs upon activation of the coagulation cascade by different concentrations of tissue factor and negatively charged phospholipids in plasma.

Researchers can choose from a range of three triggers with the kit to study different areas of coagulation mechanisms. These areas include thrombophilia, haemophilia, anticoagulation, thrombogenicity of microparticles, and drug development studies. All three triggers were tested on the SpectraMax® i3x Multi-Mode Microplate Reader with excellent results.

After generating the data in SoftMax Pro® Software the data were transferred to Technoclone’s TECHNOTHROMBIN TGA evaluation file to calculate all thrombin generation parameters based on the thrombin generation curve. This poster demonstrates that the combination of the SpectraMax i3x reader and TECHNOTHROMBIN TGA kit offers an ideal platform to perform thrombin generation assays with good precision for research use.

 

Register to download SLAS posters

 

Explore solutions for automating your 3D biology workflows

Whether you’re just starting to explore the benefits of 3D tissue models and imaging or leveraging advanced 3D workflows, we offer solutions for the complexities that come with organoid acquisition and analysis.

Visit our Organoid Innovation Center to discover our newest collaborative space bringing customers, researchers, and in-house scientists together to test automated workflows for organoid culturing and screening. Automate your 3D culture workflows and quickly adopt innovative, 3D biological methods and technologies to reduce lab costs and push the boundaries of your research.

 

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