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High-content confocal imaging solution with water objective options

The ImageXpress® Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disk confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With MetaXpress software and flexible options like water immersion objectives to choose from, the system enables many confocal imaging applications from 3D assay development to screening.

  • Acquire higher quality images

    Acquire higher quality images

    Capture excellent contrast, high resolution images with our proprietary AgileOptix™ spinning disk confocal technology, wide field of view, and bright light source.

  • Customize image acquisition and analysis

    Customize image acquisition and analysis

    Take ultimate control over acquisition and analysis parameters, which enables many applications from 3D structure analysis to target imaging of specific objects within an organism or cell populations. Run more applications with standard options like water immersion objectives, environmental control, or any of our high-performance customizations.

  • Analyze more data in less time

    Analyze more data in less time

    MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.

 ImageXpress Micro Confocal Virtual Tour

ImageXpress Micro Confocal Virtual Tour

Features

  • Wide dynamic range

    Quantify low and high intensity signals in a single image with >3 log dynamic range intensity detection.

  • Exclusive AgileOptix spinning disk confocal

    The technology provides increased sensitivity with specially designed optics, high-powered, solid state light engines, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.

  • Wide field of view

    Wide field of view enables whole-well confocal imaging and eliminates missed targets.

  • Optional on-board robotic fluidics

    For assays that involve compound addition, well washing, and media exchange, optional on-board robotic fluidics are available.

  • Accurate 3D measurements

    MetaXpress 3D analysis module is optimized for confocal imaging, enabling 3D measurements of volume and distance.

  • Multiple imaging modes

    The system offers phase contrast and brightfield label-free imaging, fluorescence, widefield, colorimetric, and confocal imaging, as well as, water immersion imaging as a standard option.

AgileOptix spinning disk technology

Our proprietary AgileOptix technology enables the ImageXpress Micro Confocal system to deliver the sensitivity and throughput needed for demanding applications.

AWES Illustration

 

 

 

 

Gain deeper insights into cellular 3D structures with water immersion objectives

This video presentation details how high-performance water immersion objectives on the ImageXpress Micro Confocal system enhance the resolution, sensitivity and throughput for a variety of complex 3D cell-based assays.

*As a supporter of, and participant in, ISSCR’s 2020 Virtual, we share with you our Innovation Showcase presentation. This presentation does not represent an endorsement from or support of the ISSCR.

Gain deeper insights

 

 

Gain more insights using
high-performance customizations

자세히 알아보기

Image Imaging Widefield Confocal Comparison

 

 

Cellular Image Gallery

Micro Confocal High-Content Imaging System
ImageXpress High-content imaging solution
ImageXpress Micro Confocal Imaging System
ImageXpress Micro Imaging System
Micro Confocal Imaging System
 
Data and images were acquired during development using customer samples. Results may vary. Highlighted features’ price, time to deliver, and specifications will vary based on mutually agreed technical requirements. Solution requirements may cause adjustment to standard performance.

 

 

 

 

Introducing the MetaXpress 3D Analysis Toolkit

MetaXpress high-content image aquisition and analysis software

 

  • Meet high throughput requirements with a scalable, streamlined workflow
  • Adapt your analysis tools to tackle your toughest problems, including 3D analysis
  • Schedule automatic data transfer between third-party hardware sources and secure database
  • Set up hundreds of routinely used HCS assays using MetaXpress software modules

Applications of ImageXpress Micro Confocal High-Content Imaging System

Specifications & Options of ImageXpress Micro Confocal High-Content Imaging System

Resources of ImageXpress Micro Confocal High-Content Imaging System

프레젠테이션
동영상 및 웨비나
Immunology and Vaccine Development Workflow

Immunology and Vaccine Development Workflow

Hybridoma Workflow

Hybridoma Workflow

Automated organoid assays with 3D imaging

Disease modeling in the 21st century: Automated organoid assays with 3D imaging

Organ-on-a-chip with organoids

High-throughput, organoid-derived organ-on-a-chip systems for drug discovery and disease modelling

Unleash the power of cell painting

Unleash the power of cell painting

3D cell culture

3D cell culture, tissue clearing, & high-content imaging in the quest of effective solutions to NAFLD

Transitioning high-content assays to 3D

Transitioning high-content assays to 3D: Scientific opportunities and imaging challenges

Water Immersion Objectives & High-Content Imaging

Gain deeper insights into cellular 3D structures with water immersion objectives

AI based approach to phenotypic characterization

An AI-based approach to high-content phenotypic characterization of human iPSC-derived neuronal cells

Implementing 3D Neural Spheroids

Implementing 3D Neural Spheroids in Drug Discovery

Accelerate your Screening with Automated Imaging

Accelerate your screening with high-content and automated imaging

Microplate based Detection

Accelerating study of viral infection and therapeutics with microplate-based detection and high-throughput screening

 ImageXpress Micro Confocal Virtual Tour

ImageXpress Micro Confocal Virtual Tour

Magnetic 3D

Magnetic 3D Bioprinting, 3D Cell Culture in a 2D Workflow

Labtube Meets SLAS

LabTube Meets Molecular Devices & MIMETAS, Susan Murphy & Sebastiaan Trietsch

Plate annotation and curve fitting in MetaXpress

Plate annotation and curve fitting in MetaXpress

Plate acquisition on ImageXpress Micro Confocal using MetaXpress

Quickstart Guide: Plate acquisition on the ImageXpress Micro Confocal using MetaXpress

Review images on ImageXpress Micro Confocal using MetaXpress

Quickstart Guide: Review images on the ImageXpress Micro Confocal using MetaXpress

Image analysis on ImageXpress Micro Confocal using MetaXpress

Basic workflow from image acquisition to analysis on the ImageXpress Micro Confocal using MetaXpress

Developing High Throughput Organ on a Chip Tissue

Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging

iPSC Derived Cardiomyocytes and Neuronal Spheroids

Toxicity studies of iPSC-derived cardiomyocytes and neuronal spheroids

3D in Vitro Models

Optimizing high-content screening tools for physiologically-relevant 3D in vitro models

Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform

Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform

3D Imaging of Cancer Spheroids

3D Imaging of Cancer Spheroids

High-Content Screening for Identifying miRNAs

High-Content Screening for Identifying miRNAs

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Oliver Kepp and Jayne Hesley - Detect Cell Death Signatures with High Content Imaging

Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging

Multidimensional ImageXpress Micro Confocal System

Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System

Pushing the Boundaries of High Content Screening

Pushing the Boundaries of High Content Screening

Preparing Assays for Genome-wide RNAi Screens

Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy

Multiplexed High Content Hepatoxicity Assays

Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes

High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models

High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 Tissue Models

Simple and Flexible High Content Imaging of Complex Biological Events

Simple and Flexible High Content Imaging Enabling Quantitation of Complex Biological Events

Contemporary Automation and High Content Imaging Tools

Contemporary Automation and High Content Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes

3D Image Analysis from Subcellular Structures to Spheroids

Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids

Live Cell Imaging to Investigate Cell Division Timing

Live Cell Imaging to Investigate the Regulation of Cell Division Timing

High-throughput RNA Screening to Identify Host Factors

Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection

Application of HCA Tools for Antibody Drug Discovery

Application of HCA Tools for Antibody Drug Discovery

3D Spheroid Assays Using High-Content Imaging

Setting up 3D Spheroid Assays Using High-Content Imaging

Physiologically-relevant tissue models using a high-throughput Organ-on-a-Chip platform

Physiologically-Relevant Tissue Models Using a High-Throughput Organ-on-a-Chip Platform

Pluripotent Stem Cell Applications in Drug Discovery

Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery

StemoniX microBrain 3D Assay

StemoniX microBrain 3D Assay Ready Plates for HTS

Related Products & Services of ImageXpress Micro Confocal High-Content Imaging System

Expand your research using flexible imaging solutions

Molecular Devices provides flexible options for the ImageXpress Micro Confocal High-Content Imaging System to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more. With over 30+ years of imaging expertise, we can help you select the right options to ensure the best images for your assay.

 

Standard hardware options

 
 

Water Immersion Objectives

Water immersion objectives can offer signal increases of up to 4 times which can help scientists see deeper into 3D and thick tissue samples at lower exposure times.


 

High-performance customizations

Molecular Devices can successfully tailor the ImageXpress Micro Confocal High-Content Imaging System to include customized software and hardware including the features described below, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.

Sale is subject to our Custom Product Purchase Terms available at www.moleculardevices.com/custom-products-purchase-terms

High-Intensity Lasers

High output laser excitation can reduce exposure times by up to 75%.† The laser light source is available as either a 5-channel or 7-channel light source with outputs of 400 —1,000 mW/channel. The 7-channel laser light source Includes near IR and is ideal for customers with increased multiplexing requirements.

  • Obtain sharper images with higher signal-to-noise
  • Generate up to a 2X† boost in scan speed attributed to significantly reduced exposure times
  • Run FRET experiments using lasers for CFP and YFP
Standard
Standard Intensity Image
Laser
high-intensity-lasers-image-new-thumbnail

 

Images taken at the same exposure.

Deep tissue penetrating, confocal disk module

An upgrade to the deep tissue penetrating, confocal disk module, combined with a laser light source, can improve resolution when imaging thick tissue samples†.

  • Improve suppression of out-of-focus light
  • Reduce haze (pinhole crosstalk)
  • Penetrate deeper into thick tissue samples for sharper images
Standard spinning disk
Standard Spinning Disc
Deep tissue penetrating, confocal disk module
Deep Tissue Penetrating with Confocal Disk

Images taken at the same exposure.

Data and images were acquired during development using customer samples. Results may vary. Highlighted features’ price, time to deliver, and specifications will vary based on mutually agreed technical requirements. Solution requirements may cause adjustment to standard performance.

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