Citations : FilterMax F3 & F5 Multi-Mode Microplate Readers

Existing approaches to array fusion can deal with straight-line producer consumer pipelines, but cannot fuse branching data flows where a generated array is consumed by several different consumers. Branching data flows are common and natural to write, but a lack of fusion leads to the creation of an intermediate array at every branch point. We present a new array fusion system that handles branches, based on Waters's series expression framework, but extended to work in a functional setting. Our system also solves a related problem in stream fusion, namely the introduction of duplicate loop counters. We demonstrate speedup over existing fusion systems for several key examples.

Drug repositioning has been considered a promising approach to discover novel treatments against neglected diseases. Among the major protozoan diseases, leishmaniasis remains a public health threat with few therapeutic alternatives, affecting 12 million people in 98 countries. In this study, we report the in vitro antileishmanial activity of the imidazole drugs clotrimazole, and for the first time in literature, econazole and bifonazole and their potential action to affect the regulation of reactive oxygen species (ROS) of the parasites. The lethal action of the imidazoles was investigated using spectrofluorimetric techniques to detect ROS content, plasma membrane permeability, and mitochondrial membrane potential. The imidazoles showed activity against L.

From a previous screening of Brazilian biodiversity for antitrypanosomal activity, the n-hexane extract from twigs of Nectandra oppositifolia (Lauraceae) demonstrated in vitro activity against Trypanosoma cruzi.